Ischemic postconditioning regulates cardiomyocyte autophagic activity following ischemia/reperfusion injury
نویسندگان
چکیده
منابع مشابه
Attenuation of Focal Cerebral Ischemic Injury Following Post-Ischemic Inhibition of Angiotensin Converting Enzyme (ACE) Activity in Normotensive Rat
Background: Central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. Our previous work showed that inhibition of angiotensin converting enzyme (ACE) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (I/R) injuries. This study evaluated the impacts of post-ischemic inhibition of ACE, enalapril, on brain inf...
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Heart disease often culminates into a decline in function and heart failure as a result of the loss of viable cardiac tissue. Given the global burden of heart disease, a lot of effort is currently dedicated toward the development of strategies that can regenerate the human heart. Although the heart is notoriously resistant to regeneration, recent studies have shown that it provides some opportu...
متن کاملDelayed Postconditioning Protects against Focal Ischemic Brain Injury in Rats
BACKGROUND We and others have reported that rapid ischemic postconditioning, interrupting early reperfusion after stroke, reduces infarction in rats. However, its extremely short therapeutic time windows, from a few seconds to minutes after reperfusion, may hinder its clinical translation. Thus, in this study we explored if delayed postconditioning, which is conducted a few hours after reperfus...
متن کاملInhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning.
Ischemic preconditioning (Pre-con) is an adaptive response triggered by a brief ischemia applied before a prolonged coronary occlusion. We tested the hypothesis that repetitive ischemia applied during early reperfusion, i.e., postconditioning (Post-con), is cardio-protective by attenuating reperfusion injury. In anesthetized open-chest dogs, the left anterior descending artery (LAD) was occlude...
متن کاملProtective effect of ischemic postconditioning against hepatic ischemic reperfusion injury in rat liver
PURPOSE The efficiency of ischemic postconditioning (IPC) was evaluated in a rat model of ischemic liver. Concentration of survivin of liver tissue correlated with the degree of antiapoptosis, so survivin was estimated to evaluate the efficiency of IPC on ischemic reperfusion (IR) injury. METHODS Twenty-four healthy rats were divided to three groups (SHAM, IR, and IPC). Rats in the SHAM group...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2012
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2015.3533